CyberKnife vs Gamma Knife and Headframes

by | Jun 15, 2025 | CyberKnife vs Gamma Knife

 

CyberKnife and headframes (often used with Gamma Knife) are both stereotactic radiosurgery techniques, but they differ significantly in how they immobilize patients and deliver radiation. CyberKnife is non-invasive, using a lightweight mask and real-time tracking, while headframe systems involve a rigid frame bolted to the skull. 

Here’s a more detailed comparison:

CyberKnife:
  • Non-invasive:

    Uses a custom-fitted, lightweight mesh mask to stabilize the head and neck. 

  • Real-time tracking:

    Employs sophisticated technology to track tumor movement during treatment, allowing for accurate targeting even if the patient moves slightly. 

  • Flexible treatment:

    Can deliver radiation from thousands of angles, allowing for precise targeting and potentially minimizing damage to surrounding healthy tissue. 

  • Treats a wider range of tumors:

    Can treat tumors throughout the body, including those in the brain, head, neck, spine, lung, prostate, liver, and pancreas. 

  • Multiple treatment sessions:

    Can deliver radiation in multiple lower doses over a few days, or a single, higher dose. 

Headframes (e.g., Gamma Knife):

 

  • Invasive: Requires a head frame to be rigidly fixed to the skull with screws. 
  • Static imaging: Relies on pre-treatment imaging to determine tumor location, and the patient is immobilized during treatment. 
  • Limited angles: Radiation is delivered from a fixed set of angles, which may limit the ability to spare surrounding healthy tissue. 
  • Primarily used for brain and spinal tumors: While some headframe systems can be used for other areas, they are primarily used for brain and spinal tumors. 
  • Typically single high-dose treatment: Often delivers a single, high-dose treatment. 
In essence, the key difference lies in the method of immobilization and the flexibility of radiation delivery. CyberKnife offers a more comfortable and flexible approach, while headframes provide a very rigid and precise, but more invasive, method.